Can First-trimester AST to Platelet Ratio Index Scores Predict HELLP Syndrome?

OBJECTIVE To determine whether the ratio of first-trimester aspartate aminotransferase (AST) to platelet index (APRI) score will be useful as a new determinant hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome that may develop in later stages pregnancy Study Design: Descriptive-analytical study. PLACE AND DURATION OF STUDY Perinatology Clinic Etlik Zubeyde Hanim Maternity and Women's Health Teaching Research Hospital, Ankara, Turkey. The data patients diagnosed having HELLP between 2018 2020 were analyzed retrospectively. METHODOLOGY Forty-two pregnant women with study group 74 no morbidities control included First-trimester APRI scores compared for both groups. A characteristic curve (ROC) analysis was performed levels predicting syndrome. RESULTS One hundred sixteen had significantly lower fibrinogen (PLT) than without (p<0.001). Women higher ALT, AST, creatinine, INR levels. These differences different who developed third trimester (0.64±0.10) (0.40±0.12, p<0.001). In ROC analysis, 0.55 cut-off value sensitivity 88.1 % specificity 94.6 developing pregnancy. CONCLUSION There an association prediction syndrome, possibly weeks Predicting early period can assist proper management taking necessary precautions. Key Words: prediction, APRI, pregnancy, score.